Flamingo, Florida, is the end of the road — literally. Located 38 miles southwest of the Everglades National Park entrance, the area offers incredible hiking, canoeing, and bicycling. It's the perfect place to bird watch too. There's also a campground with (cold) showers and the thrilling knowledge you're as far south as you can get in the contiguous United States. But regardless of whether you're there for a day picnic or a weekend blowout, DEET is a must. Even riding the Snake Bight trail at a fast clip isn't enough to shake those aggressive Everglades skeeters. And if you're walking the trails, use a hat with a net, or a suit of armor.