Considered one of the finest charities in the nation, the Susan G. Komen Breast Cancer Foundation is a model of how a charity should work. Administrative costs are kept down while a significant percentage of funds raised through local affiliates remains in the communities where the money was donated. This race qualifies as the big-money benefit for a great cause. Approximately 1.5 million runners participate in the 5K run/walk, which is conducted in many locations. The local race takes place every October in Bayfront Park, winding its way through downtown and the Brickell area. (There's also a race in West Palm Beach.) Runners are separated into divisions that include one specifically for survivors of breast cancer. You can also join a one-mile walk or enter your kids in the tot run. Ceremonies pay tribute to cancer victims and celebrate the success of survivors. A good way to take over downtown (known to shut down completely for the filming of terrible Hollywood movies) for a cause that matters.